08/03/2018
Marie Skłodowska-Curie Actions

14 PhD student positions, Early Stage Researchers, for a Marie Curie ITN project on the discovery of neurotrophins small molecule mimetics as candidate therapeutic agents for neurodegeneration and neuroinflammation

This job offer has expired


  • ORGANISATION/COMPANY
    National Hellenic Research Foundation
  • RESEARCH FIELD
    Biological sciences
    ChemistryBiochemistry
    ChemistryComputational chemistry
    ChemistryOrganic chemistry
    Computer science3 D modelling
    Computer scienceModelling tools
    NeurosciencesNeurobiology
    NeurosciencesNeurochemistry
    NeurosciencesNeurology
    Pharmacological sciencesPharmacognosy
    Pharmacological sciencesPharmacy
    PhysicsBiophysics
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    20/04/2018 20:00 - Europe/Athens
  • LOCATION
    Multiple locations, see work locations below.
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/09/2018
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • MARIE CURIE GRANT AGREEMENT NUMBER
    765704

EuroNeurotrophin offers 14 Early Stage Researcher (ESR) positions across Europe.

EuroNeurotrophin is looking for skilled and highly motivated young scientists to be trained in drug discovery and development with a focus on the design, synthesis and isolation of new neuroprotective small molecule neurotrophin mimetics and their assessment using multimodal experimental and computational approaches, as well as their translation towards market applications. The ESRs will be enrolled in Ph.D. programmes and will be employed for 36 months. The consortium comprises 12 leading European research groups and 6 private companies with complementary expertise covering all steps of drug discovery and development.

ESR1: Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by five or six membered-17-spiro substituents

Host Institution: National Hellenic Research Foundation (NHRF), Athens, Greece (36 months)

ESR2: Synthesis of dehydroepiandrosterone (DHEA) derivatives substituted by three membered-17-spiro substituents

Host Institution: National Hellenic Research Foundation (NHRF), Athens, Greece (36 months)

ESR3: Computer-aided molecular design

Host Institution: Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany (36 months)

ESR4: Modelling of mechanistic effects of neurotrophin modulators

Host Institution: Heidelberg Institute for Theoretical Studies (HITS), Heidelberg, Germany (36 months)

ESR5: Production of purified protein targets and x-ray crystal structure determination of target-ligand complexes

Host Institution: University of Siena (UNISI), Siena, Italy (36 months)

ESR6: In silico screening and Hit to lead development of small molecules neurotrophin receptors ligands

Host Institution: Universite de Caen Normandie (UNICAEN), Caen, France (36 months)

ESR7: Isolation of new natural neurotrophin mimetics from marine microorganisms

Host Institution: National and Kapodistrian University of Athens (NKUA), Athens, Greece (36 months)

ESR8: Evaluation of small molecule neurotrophin mimetics in models of neurodegeneration and neuroinflammation

Host Institution: Technische Universitat Dresden (TUD), Dresden, Germany (36 months)

ESR9: Development of Human Cell-Based Models for study of Blood Brain Barrier Molecular Permeability

Host Institution: AvantiCell Science Ltd (ACS), Scotland, UK (36 months)

ESR10: Development of Human Cell-Based Models for Neurotrophic Therapeutic Testing

Host Institution: AvantiCell Science Ltd (ACS), Scotland, UK (36 months)

ESR11: Evaluation of activity on neurotrophin receptors and their role in signaling, in in vitro and in vivo neurodegenerative conditions, such as AD

Host Institution: Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece (36 months)

ESR12: In vitro and in vivo effects of new synthetic and natural compounds on Neural Stem Cells and adult neurogenesis in AD

Host Institution: Foundation for Research and Technology Hellas (FORTH), Heraklion, Greece (36 months)

ESR13: Investigation of the potency of small molecule mimetics of neurotrophins to rescue the reduction in synapse number and the aberrant synapse proteome in mouse models of AD

Host Institution: VU University of Amsterdam (VUA), Amsterdam, Netherlands (36 months)

ESR14: The neuroprotective effects of neurotrophins in novel in vitro and in vivo models of Motor Neurone Disease (ALS/MND)

Host Institution: University of Sheffield (USFD), Sheffield, United Kingdom (36 months)

Benefits

  • The ESR positions are full-time with a 12 month duration renewable to 36 months.
  • A very attractive salary plus allowances package according to the allowance amounts defined in the rules for Early Stage Researchers (ESRs), EU Marie Skłodowska-Curie Actions Innovative Training Networks (ITN) (http://ec.europa.eu/research/participants/data/ref/h2020/wp/2016_2017/ma...)
  • Network-wide training in advanced research skills and training in transferable and technical skills.
  • Local specialist training provided by the host institution.
  • Intersectoral and interdisciplinary secondments within the EuroNeurotrophin network.
  • International exposure through participation in project meetings and scientific conferences.

Eligibility criteria

H2020 MSCA eligibility criteria: The researcher must not have resided or carried out his/her main activity (work, studies, etc) in the country of his/her host institution for more than 12 months in the 3 years immediately prior to his/her recruitment. Short stays, such as holidays, compulsory military service, and time spent as part of a procedure for obtaining refugee status are not taken into account.

Early Stage Researcher (ESR): Researchers who, at the time of the recruitment, have not yet been awarded a doctorate degree and are in the first four years (full-time equivalent) of their research careers, including the research training period that would entitle them to a doctorate. Full-Time-Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (even if a doctorate was never started or envisaged).

Non-research work after acquiring a master’s degree is not counted in the four years of the research career; certificates on the nature of tasks in non-research employment will be requested for shortlisted candidates.

Selection process

A first selection process will consist of a screening of the application form, curriculum vitae, motivation letter, copies of transcripts and recommendation letters. The short-listed candidates will be interviewed by teleconference/skype by the Local Recruitment Committee of each host institution. The selected candidates will be approved by the Network Recruitment Committee.

Web site for additional job details

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Chemistry: Master Degree or equivalent
    Pharmacological sciences: Master Degree or equivalent
    Biological sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

  • Educational background relevant for the chosen position. A master’s degree or equivalent (in the fields of chemistry, physics biological and pharmaceutical sciences or related) is mandatory, or should be obtained prior to the date of appointment.
  • Previous research experience relevant to the chosen position.
  • Communication skills (to be evaluated in the interview).
  • Applicants must have a very good knowledge (written and oral) of the English language.

Specific Requirements

  • Applicants can be of any nationality.
  • H2020 MSCA Mobility Rule: researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of the host organisation for more than 12 months in the 3 years immediately before the recruitment date. Compulsory national service, short stays such as holidays, and time spent as part of a procedure for obtaining refugee status are not taken into account.
  • H2020 MSCA eligibility criteria: Early Stage Researchers (ESRs) must, at the date of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree. Full-Time Equivalent Research Experience is measured from the date when the researcher obtained the degree entitling him/her to embark on a doctorate (either in the country in which the degree was obtained or in the country in which the researcher is recruited, even if a doctorate was never started or envisaged).

Work location(s)
2 position(s) available at
National Hellenic Research Foundation (NHRF)
Greece
Athens
2 position(s) available at
Heidelberg Institute for Theoretical Studies (HITS)
Germany
Heidelberg
1 position(s) available at
University of Siena (UNISI)
Italy
Siena
1 position(s) available at
Universite de Caen Normandie (UNICAEN)
France
Caen
1 position(s) available at
National and Kapodistrian University of Athens (NKUA)
Greece
Athens
1 position(s) available at
Technische Universitat Dresden (TUD)
Germany
Dresden
2 position(s) available at
AvantiCell Science Ltd (ACS)
United Kingdom
Scotland
2 position(s) available at
Foundation for Research and Technology Hellas (FORTH)
Greece
Heraklion
1 position(s) available at
VU University of Amsterdam (VUA)
Netherlands
Amsterdam
1 position(s) available at
University of Sheffield (USFD)
United Kingdom
Sheffield

EURAXESS offer ID: 286364