RESEARCH FIELDBiological sciences
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE30/03/2018 12:00 - Europe/London
LOCATIONUnited Kingdom › Cardiff
TYPE OF CONTRACTTemporary
HOURS PER WEEK35
OFFER STARTING DATE01/10/2018
Neurodevelopmental disorders are highly prevalent and severely debilitating brain illnesses caused by aberrant brain growth and development.
The etiology of neurodevelopmental disorders is still largely unclear, but immune dysfunction and abnormalities in synaptogenesis have repeatedly been implicated as contributing to the disease phenotype. It is currently unknown as how immune activation is translated into neurodevelopmental associated cellular phenotypes.
Our lab has generated disease-specific induced pluripotent stem cell lines from patients carrying mutations that significantly increase the risk for manifestation of neurodevelopmental disorders.
Project aims and methods
The project aim is to understand, at the molecular level, how disease-associated genetic variants affect immune cell metabolism, and how immune responses affect the neurodevelopment using neural organoid culture.
This project will be based in the Neuroscience and Mental Health Research Institute, with access to state-of-the-art facilities. This project offers a unique opportunity for you to learn molecular (e.g. lentiviral construction, cloning, siRNA/miRNA mediated gene knockdown and genomic techniques to assess the transcriptome) imaging (confocal, high content screeing), biochemical (measurements of cellular bioenergetics, assays of mitochondrial function) and stem cell biology (culturing of cerebral organoids, glial cells derived from human iPS cells carrying copy number variants that are implicated in neurodevelopmental disorders).
As well as the specific training detailed above, you will have access to a wide-range of seminars and training opportunities through the many research institutes and centres based at Cardiff University.
Doctoral stipend matching UK Research Council National Minimum
Please apply to the Doctor of Philosophy in Biosciences with an October 2018 start date.
In the “Research Proposal and Funding” section of your application, please specify the project title and supervisors of this project and copy the project description in the text box provided
Please select “No, I am not self-funding my research” when asked whether you are self-funding your research.
Please add “PhD in Biosciences: Investigating the role of inflammatory system in the pathogenesis of neurodevelopmental disorder" when asked "Please provide the name of the funding you are applying for."
Please include contact details for two referees, your CV, and a motivation letter stating your scientific interests, background and previous research experience.
Applicants are expected to hold, or about to obtain, a minimum upper second-class undergraduate degree (or equivalent) in a subject related to biological sciences. A masters degree, with research experience, in stem cells and regenerative medicine, or biomaterials would beneficial.
Open to all UK/EU students without further restrictions
EURAXESS offer ID: 286361