ORGANISATION/COMPANYInstitut de Génétique Moléculaire de Montpellier CNRS 5535
RESEARCH FIELDBiological sciences › BiologyMedical sciences
RESEARCHER PROFILERecognised Researcher (R2)
APPLICATION DEADLINE09/03/2018 22:00 - Europe/Brussels
LOCATIONFrance › Montpellier
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE30/03/2018
Project: The role of CAR during adult neurogenesis
The significant advances in healthy care and quality of life during the last seven decades have resulted in an
increase in the incidence of age-related neurodegenerative diseases. In the brain, cell adhesion molecules
(CAMs) are involved in neurogenesis, neurite outgrowth, target recognition during synaptogenesis and in the
stability of synapses. Mutations in or impairment of CAM functionality are associated with neurologic and
psychiatric diseases. The coxsackievirus adenovirus receptor (CAR) is a type I transmembrane protein belonging
to the Ig superfamily. CAR is expressed in neurons throughout the brain, but its physiological function is poorly
characterized. We found that CAR loss of function - induced genetically or via an inflammatory response - in the
neurogenic niches is linked with perturbed neurogenesis, behaviour, LTP and synapse content. Our goal is to
better understand the role of CAR in the healthy and diseased brain, especially related to cognitive impairment.
Social and health care costs are covered buy the contract.
Salary for the first year is provided by EpiGenMed (http://www.epigenmed.fr ). The initial contract is
for 1 year, and the contract is potentially renewable for 3-4 years
PhD in neurobiology, cell biology of brain cells, and/or adult neurogenesis.
Please provide 1) a letter that explains the reasons for being interested in this project/lab,
2) a CV with list of publications and,
3) contact details for 3 previous mentors, or someone who closely followed your research activities.
Application should be sent to (email@example.com )
Schwarz et al. Viral-genetic tracing of the input–output organization of a central norepinephrine circuit. Nature 2015 Aug
Beier et al, Circuit Architecture of VTA Dopamine Neurons Revealed by Systematic Input-Output Mapping. Cell 2015 Jul
Junyent et al. CAV-2 - why a canine virus is a neurobiologist’s best friend. Curr Op Pharm 2015 Oct (24)86–93.
Salinas et al. Disruption of the coxsackievirus and adenovirus receptor- homodimeric interaction triggers lipid microdomainand
dynamin-dependent endocytosis and lysosomal targeting J. Biol. Chem. 2014 10;289(2):680-95
Kremer EJ & GR Nemerow. An adenovirus’ tale: from the plasma membrane to the nuclear pore complex. PLoS Pathogens,
2015 Jun 4;11(6):e1004821.
Zussy et al. Coxsackievirus adenovirus receptor loss impairs adult neurogenesis, synapse content & hippocampus plasticity. J
Salinas S, Junyent F, Coré N, Cremer H, Kremer EJ. What is CAR doing in the middle of the adult neurogenic road?
Neurogenesis. 2017 Apr 27;4(1):e1304790
Hirschberg S, Li Y, Randall A, Kremer EJ, Pickering AE. Functional dichotomy in spinal- vs prefrontal-projecting locus
coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats. eLife. 2017 Oct
13;6. pii: e29808.
Uematsu et al Modular organization of the brainstem noradrenaline system coordinates opposing learning states. Nat
Neurosci. 2017 Nov;20(11):1602-1611.
Required Research Experiences
YEARS OF RESEARCH EXPERIENCE1 - 4
REQUIRED EDUCATION LEVELNeurosciences: PhD or equivalent
REQUIRED LANGUAGESENGLISH: Good
Ideally competence and/or familiarity with: confocal microscopy, handling transgenic mice, stereotactic injections,
cell biology, histology, biochemistry, molecular biology techniques, electrophysiology and behaviour assays.
Strong presentation and writing skills, capability of working in a team, and independently, and fluency in English
are primordial skills.
Ph.D. in neurobiology or closely related discipline with <2 years of relevant post-doc experience.
EURAXESS offer ID: 279031