09/02/2018

Post doc position


  • ORGANISATION/COMPANY
    CNRS
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    Recognised Researcher (R2)
  • APPLICATION DEADLINE
    09/03/2018 22:00 - Europe/Brussels
  • LOCATION
    France › Montpellier
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    23/02/2018

Innate and trained immunity of antigen presenting cells challenged with

While numerous studies have addressed the cellular and humoral response to primary virus encounters,

relatively little is known about the interplay between persistent infections, immune responses, and antigenpresenting

cells. Following repeated encounters with ubiquitous human adenoviruses (HAdVs), which

predominantly cause mild self-limiting symptoms, most of us develop robust humoral and cellular immune

responses that are thought to act together to combat subsequent infections. Yet, HAdVs can establish

persistent, subclinical infections that last for decades. However, if ones T-cell immunity is severely

compromised, reactivation of persistent HAdV constitutes a life-threatening risk. By contrast, HAdV infections

pose minimal risk in B-cell compromised individuals. This dichotomy led us to ask how anti-HAdV antibodies

and other serum components influence HAdV immune responses. We address these questions using human

DCs (plasmacytoids, conventional & Langerhans), T cells (naïve, memory & regulatory), and serum

components. We use transcriptome and secretome profiling, and pharmacological, biochemical, genetic,

molecular, and cell biology approaches to address our questions.

adenoviruses and serum components

Benefits

All social and health care benefits are provided by the CNRS

Eligibility criteria

PhD in cell biology of immune cells, virology and/or immunology. 

Selection process

CVs will be screened for pertin,ent competences and candidates will be invited for interviews either in person or via Skype.

The final decision will be made by EJ Kremer 

Additional comments

Application: Please provide 1) a letter that explains the reasons for being interested in this project, 2) a CV with list of publications and, 3) contact details for 3 previous mentors, or someone who closely followed your research activities

Relevant lab publications ( https://www.ncbi.nlm.nih.gov/sites/myncbi/16AzQws5ttFkm/bibliography/451... )

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Good

Skills/Qualifications

 Ideally competence and/or familiarity with confocal microscopy, cell biology, flow cytometry, molecular biology

techniques. Strong presentation and writing skills, capability of working in a team and independently, and capable of

communicating in English are primordial skills.

Specific Requirements

Requirements: Ph.D. in virology, cell biology, immunology or closely related discipline with <2 years of

relevant post-doc experience.

Map Information

Job Work Location Personal Assistance locations
Work location(s)
1 position(s) available at
CNRS
France
N/A
Montpellier
34292
1919 route de Mende

EURAXESS offer ID: 279025