RESEARCH FIELDBiological sciences › Biology
RESEARCHER PROFILERecognised Researcher (R2)
APPLICATION DEADLINE09/03/2018 22:00 - Europe/Brussels
LOCATIONFrance › Montpellier
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE23/02/2018
Innate and trained immunity of antigen presenting cells challenged with
While numerous studies have addressed the cellular and humoral response to primary virus encounters,
relatively little is known about the interplay between persistent infections, immune responses, and antigenpresenting
cells. Following repeated encounters with ubiquitous human adenoviruses (HAdVs), which
predominantly cause mild self-limiting symptoms, most of us develop robust humoral and cellular immune
responses that are thought to act together to combat subsequent infections. Yet, HAdVs can establish
persistent, subclinical infections that last for decades. However, if ones T-cell immunity is severely
compromised, reactivation of persistent HAdV constitutes a life-threatening risk. By contrast, HAdV infections
pose minimal risk in B-cell compromised individuals. This dichotomy led us to ask how anti-HAdV antibodies
and other serum components influence HAdV immune responses. We address these questions using human
DCs (plasmacytoids, conventional & Langerhans), T cells (naïve, memory & regulatory), and serum
components. We use transcriptome and secretome profiling, and pharmacological, biochemical, genetic,
molecular, and cell biology approaches to address our questions.
adenoviruses and serum components
All social and health care benefits are provided by the CNRS
PhD in cell biology of immune cells, virology and/or immunology.
CVs will be screened for pertin,ent competences and candidates will be invited for interviews either in person or via Skype.
The final decision will be made by EJ Kremer
Application: Please provide 1) a letter that explains the reasons for being interested in this project, 2) a CV with list of publications and, 3) contact details for 3 previous mentors, or someone who closely followed your research activities
Relevant lab publications ( https://www.ncbi.nlm.nih.gov/sites/myncbi/16AzQws5ttFkm/bibliography/451... )
REQUIRED LANGUAGESENGLISH: Good
Ideally competence and/or familiarity with confocal microscopy, cell biology, flow cytometry, molecular biology
techniques. Strong presentation and writing skills, capability of working in a team and independently, and capable of
communicating in English are primordial skills.
Requirements: Ph.D. in virology, cell biology, immunology or closely related discipline with <2 years of
relevant post-doc experience.
EURAXESS offer ID: 279025