06/02/2018

PhD Student in Experimental Nephrology

This job offer has expired


  • ORGANISATION/COMPANY
    Idibell
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    09/03/2018 12:00 - Europe/Brussels
  • LOCATION
    Spain › Barcelona (Hospitalet de Llobregat)
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    15/03/2018

The position

The PhD student will investigate the effect of macrophages and some of their secreted factors in the proliferation of Bowman's capsule parietal cells (PECS) in extracapillary proliferative glomerulonephritis. The student will use in vivo and in vitro approaches as well as human samples. The objective of the project is based in real translational results in order to design new therapeutic strategies targeting PECs to reduce the severity of the lesion and improve its prognosis.

The group

Summary

Crescentic glomerulonephritis (GNEC) is the most severe form of renal injury with morphological manifestations of glomerular leading to the rapid deterioration of renal function (weeks). The infiltrating macrophages have been classically described as the potential source of the crescents. However, the parietal epithelial cells of the Bowman capsule (PECs) are currently accepted as the overwhelming predominant cell type in the crescents.

Thus, macrophages participate in glomerular inflammation and PECS are the origin of the crescent, although the signalling pathways that activate its proliferation are still only partially understood. With this project, we will decipher signalling pathway of soluble factors derived from macrophages in the activation and proliferation of human PECs.

 

Benefits

FPI

fellowship: Free tuition and salary funded by the Spanish Government in a funded national project. (http://www.isciii.es/ISCIII/es/contenidos/fd-investigacion/fd-financiacion/fd-convocatorias-ayudas-accion-estrategica-salud/convocatoria-aes.shtml)

Additional comments

Please send your CV and academic record before 9th March to:

Anna Sola (asola@idibell.cat)

Roser Guiteras (rguiteras@idibell.cat

Required Research Experiences

  • RESEARCH FIELD
    Biological sciencesBiology
  • YEARS OF RESEARCH EXPERIENCE
    1 - 4

Offer Requirements

  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

- Degree/ MSc in Biology, Biotechnology , Veterinary or related disciplines.

- Minimum academic record 7,5/10

Specific Requirements

- It is worthwhile to be in possession of the animal experimentation course

- Prior experience in laboratory tasks will be assessed

- English language

Work location(s)
1 position(s) available at
Idibell
Spain
Spain
Barcelona (Hospitalet de Llobregat)
08908
Gran Via Hospitalet, 199-203

EURAXESS offer ID: 277954