17/03/2017
Marie Skłodowska-Curie Actions  SME OFFER

First Stage Researcher (R1)

This job offer has expired


  • ORGANISATION/COMPANY
    Neuroscience Technologies SLP
  • RESEARCH FIELD
    Biological sciencesBiological engineering
    Computer scienceComputer systems
    Computer scienceInformatics
    Computer scienceProgramming
    Medical sciencesMedicine
    NeurosciencesNeurobiology
    NeurosciencesNeurophysiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    19/06/2017 23:00 - Europe/Brussels
  • LOCATION
    Spain › Barcelona
  • TYPE OF CONTRACT
    Temporary
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40
  • OFFER STARTING DATE
    01/11/2017
  • EU RESEARCH FRAMEWORK PROGRAMME
    H2020 / Marie Skłodowska-Curie Actions
  • REFERENCE NUMBER
    ESR4 & ESR5
  • MARIE CURIE GRANT AGREEMENT NUMBER
    721841

Project: ITN PAIN-net

Neuropathic pain affects 5% of the general population and 40% of patients with neurological diseases, and has a key role in the pathophysiology of cancer pain that affects up to 50% of patients in the early disease stage and 30% of survivors, causing an enormous social burden. Treatments are inadequate with less than 50% of patients achieving 50% of pain relief at best, while up to 30% of cancer pain patients experience insufficient analgesia. Signatures of individual susceptibility to pain and analgesic responsiveness are urgently needed to improve patients’ management. Such advances are expected to originate from integrated clinical, basic science and entrepreneurial research readily translating scientific findings into benefits for patients. To consolidate these aims, a new generation of scientists with wide knowledge in neuropathic pain, focused research skills and experience in the interaction with biotechnology companies is needed. The PAIN-Net programme, based on a highly innovative platform of training-through-research and strongly committed to such objectives, will support such talented and inspired early stage researchers. Their research projects, embedded in an advanced molecule-to-man pain network, will contribute to better understanding individual susceptibility to pain and analgesics responsiveness based on next generation sequencing, whole exome sequencing, epigenetics and pharmacogenomics studies, nociceptor and sodium channel functioning based on biophysics and proteomics studies, targeted analgesics based on high-throughput screening, targeted analgesic delivery based on encapsulated cell bioreactor implants, and to the development and extensive characterisation of the first knock-in mouse models of sodium channel-related neuropathic pain based on the CRISP-Cas technology. Most of all, the PAIN-Net programme will offer the unique opportunity to enhance scientific capabilities and prepare to high level academic or private applied research career.

Specific Research Project

ESR4 will assess excitability and spontaneous activity of C-nociceptors to identify the key readouts that correspond to the experienced intensity of pain. Microneurography recording of spontaneous discharge of different classes of nociceptors and quantification of their excitability will be performed in 50 neuropathic pain patients and 30 controls collected using the same diagnostic criteria described in WP1 (Task1.2). The topical capsaicin/heat rekindling model l55 will be used to validate the readouts for spontaneous activity in patients by comparing them to capsaicin/heat-induced spontaneous activity in controls. We will use one model of nociceptor sensitisation (NGF). Spontaneous activity and nociceptor excitability will be compared to classical patient readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Evoked Potentials). Measures of spontaneous activity and excitability of nociceptors will be performed in the new CRISPR-Cas mouse model within the characterisation protocol.

ESR5 is expected to learn microneurography techniques and their use in animal models of neuropathic pain. Mainly, the ESR5 is expected to establish an automated method to analyse and quantify the spontaneous activity of primary afferent nociceptors through the implementation of dedicated software and/or the software/hardware interfaces needed. This method will be validated through pharmacological interventions aimed to modify the nociceptors response observed in the microneurography.

Benefits

ESR4

Project Title: Electrophysiology of individual peripheral nociceptors

Training objectives: ESR4 will assess excitability and spontaneous activity of C-nociceptors to identify the key readouts that correspond to the experienced intensity of pain. Microneurography recording of spontaneous discharge of different classes of nociceptors and quantification of their excitability will be performed in 50 neuropathic pain patients and 30 controls collected using the same diagnostic criteria described in WP1 (Task1.2). The topical capsaicin/heat rekindling model l55 will be used to validate the readouts for spontaneous activity in patients by comparing them to capsaicin/heat-induced spontaneous activity in controls. We will use one model of nociceptor sensitisation (NGF). Spontaneous activity and nociceptor excitability will be compared to classical patient readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Evoked Potentials). Measures of spontaneous activity and excitability of nociceptors will be performed in the new CRISPR-Cas mouse model within the characterisation protocol.

Research Objectives: 1) To perform microneurographic recording of spontaneous discharge of different classes of nociceptors and quantify their excitability in peripheral neuropathic pain patients, healthy subjects and in the new knock-in mouse model.

Expected Results: The project will assess excitability and spontaneous activity of Cnociceptors to identify the key readouts that correspond to the experienced intensity of pain in patients in order to generate and validate models of spontaneous pain in humans, and compare findings with classical nociceptor readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Evoked Potentials). The project is also expected to establish a new model for tonic evoked nociceptor activity using the topical capsaicin/heat-rekindling model. Microneurographic recording of nociceptor activity will be also performed within the characterisation of the knock-in mouse models of neuropathic pain.

Planned secondment(s): to familiarise with painful neuropathy patients and learn advanced genetic techniques;  to characterise the Knock-in mouse model by nociceptive threshold and skin biopsy. To learn transgenic mouse model development and management; to receive practical training on grant writing and project management (UM, Netherlands; FINCB, Italy; CFc, Italy).

Supervisor: Jordi Serra

 

ESR5

Project Title: Development of analysis software for the detection and quantification of spontaneous activity in peripheral nociceptors

Training objectives: ESR5 will perform the analysis of algorithms for single C-fibre recordings which results will allow the harmonisation of the stimulation protocols, recording software and analysis software between human microneurography and rodent single fibre recordings such that the results can be included in the common analysis approach.

Research Objectives: 1) To establish common recording and analysis algorithms and develop software for microneurography; 2) To develop automated method for the quantification of spontaneous activity in nociceptors; 3) To validate paradigm analysis through pharmacological intervention in animal models of neuropathic pain.Expected Results: Harmonisation of animal and human electrophysiological approach and develop software for the analysis of microneurography data.

Expected Results: The project will assess excitability and spontaneous activity of Cnociceptors to identify the key readouts that correspond to the experienced intensity of pain in patients in order to generate and validate models of spontaneous pain in humans, and compare findings with classical nociceptor readouts (Quantitative Sensory Testing, Nerve Conduction Studies, Evoked Potentials). The project is also expected to establish a new model for tonic evoked nociceptor activity using the topical capsaicin/heat-rekindling model. Microneurographic recording of nociceptor activity will be also performed within the characterisation of the knock-in mouse models of neuropathic pain.

Planned secondment(s): to learn bioinformatics tools for targeted genetics;  to learn bioinformatics tools for sodium channel modelling; to learn bioinformatics tools for unbiased genetics; to learn bioinformatics tools on epigenetics; to receive practical training on grant writing and project management (Yale,United States; OSR,Italy; UNIBO, Italy; CFc, Italy)

Supervisor: Elizabeth Garcia-Perez

 

ESR4 & ESR5

Benefits

1. Employment contract (3yrs) with salary and mobility component

2. Exposure to a highly international scientific environment

3. Transferable skills: Ethics/ Laboratory conduct/ Grant writing/ Results exploitation/ Presentations/ Pan-European meetings

Transferable skills: Ethics/Scientific conduct/Project management/Grant Writing/Communication/Exploitation of results/Research development career

EU RESEARCH FRAMEWORK PROGRAMME

Salary according to H2020 / Marie Skłodowska-Curie Actions: MARIE CURIE GRANT AGREEMENT NUMBER 721841

Eligibility criteria

ESR4  A degree in Medicine, preferably with specialization in Clinical Neurophysiology or Neurology - Candidate must be eligible for certification to practise medicine in Spain - and (ii) a strong interest in biomedical research. Considered criteria will include scientific excellence, along with criteria such as mobility experience, capacity to work in a team and good communication skills.  

ESR5 Outstanding candidates with experience in programming (C++, Matlab, Python and/or R), implementation of hardware/software interfaces for electrophysiological signal processing and a strong interest in biomedical research are required. A degree in Biotechnology, Computational Engineering/sciences, informatics or related fields would be an advantage. Further knowledge in applications of science and engineering is welcome.

ESR4 & ESR5

Ability to work in a multidisciplinary team and very good knowledge of oral and written English are required.

The candidates are required to undertake transnational mobility (i.e. move from his/her country to Spain)

First Stage Researcher (R1). Researchers shall at the time of recruitment by the host organisation, be in the first four years* (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

The researcher must not have resided or carried out his/her main activity (work, studies, etc) in Spain for more than 12 months in the 3 years immediately prior to his/her recruitment.

*is measured from the date when a researcher obtained the degree which would formally entitle him or her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher is recruited or seconded, irrespective of whether or not a doctorate is or was ever envisaged

Selection process

 

Additional comments

Neuroscience Technologies is an equal opportunities employer.

-Starting date: 01/11/2017 (if possible)

-Duration: 36 months.

Offer Requirements

  • REQUIRED EDUCATION LEVEL
    Computer science: Bachelor Degree or equivalent
    Medical sciences: Master Degree or equivalent
  • REQUIRED LANGUAGES
    ENGLISH: Excellent

Skills/Qualifications

Eligibility criteria

ESR4: degree in Medicine, preferably with specialization in Clinical Neurophysiology or Neurology - Candidate must be eligible for certification to practise medicine in Spain - and a strong interest in biomedical research. Considered criteria will include scientific excellence, along with criteria such as mobility experience, capacity to work in a team and good communication skills.  Other soft skills: international experience. Proficiency ability to read/write/speak English is required.

ESR5: Outstanding candidates with experience in programming (C++, Matlab, Python and/or R), implementation of hardware/software interfaces for electrophysiological signal processing and a strong interest in biomedical research are required. A degree in Biotechnology, Computational Engineering/sciences, informatics or related fields would be an advantage. Further knowledge in applications of science and engineering is welcome.

 

ESR4 & ESR5

Ability to work in a multidisciplinary team and very good knowledge of oral and written English are required.

The candidates are required to undertake transnational mobility (i.e. move from his/her country to Spain)

Researchers shall, at the time of recruitment by Neuroscience Technologies, be in the first four years* (full-time equivalent research experience) of their research careers and have not been awarded a doctoral degree.

The researcher must not have resided or carried out his/her main activity (work, studies, etc) in Spain for more than 12 months in the 3 years immediately prior to his/her recruitment-

Spanish would be helpful.

*is measured from the date when a researcher obtained the degree which would formally entitle him or her to embark on a doctorate, either in the country in which the degree  was obtained or in the country in which the researcher is recruited or seconded,  irrespective of whether or not a doctorate is or was ever envisaged

Specific Requirements

Your application should contain a detailed CV (with passport number, date/place of birth), a motivation letter, two letters of recommendation, and samples of your written English (e.g., prior publication /thesis excerpt) by 19/06/2017.

Applications should be sent via email to:

ESR4: Jordi Serra, jserra@nsc-tec.com

ESR5: Elizabeth Garcia-Perez , egarcia@nsc-tec.com 

Work location(s)
2 position(s) available at
Neuroscience Technologies SLP
Spain
Spain
Barcelona
08028
C/Baldiri Reixac 15-21

EURAXESS offer ID: 192003