24/01/2017

THE ROLE OF THE GUT MICROBIOME IN LIVER DISEASE: DEVELOPMENT OP BIOINFORMATIC APPROACHES TO IDENTIFY, CHARACTERISE AND ANALYSE THE GUT VIROME

This job offer has expired


  • ORGANISATION/COMPANY
    KU Leuven
  • RESEARCH FIELD
    Biological sciencesBiology
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/03/2017 23:00 - Europe/Athens
  • LOCATION
    Belgium › Leuven
  • TYPE OF CONTRACT
    Permanent
  • JOB STATUS
    Full-time
  • HOURS PER WEEK
    40

OFFER DESCRIPTION

Project

The proposed PhD position is part of the MicrobLiver project awarded to Prof. Torben Hanssen by the Novo Nordisk Foundation  (http://danishdiabetesacademy.dk/news/120-million-dkk-research-role-gut-m...). MicrobLiver deals with the physiological characterization of the human gut microbiota-liver axis, and its role in widespread metabolic disorders including non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH), and alcoholic liver disease. For this project the Laboratory of Viral Metagenomics is responsible for the investigation of the virus component of the gut microbiome. The virome will be studied using a recently in-house developed metagenomics protocol (NetoVIR; http://www.nature.com/articles/srep16532) to study the virome in stool samples using high-throughput Illumina Next Generation Sequencing technologies. These projects will results in billions of generated sequence reads, most of which belong to known and unknown bacteriophages, in addition to eukaryotic viruses. The further analysis and characterization of these data is hampered by several factors including lack of complete, curated databases. The PhD candidate will be responsible for the development of a strategy to identify and characterize these novel viruses to generate a viral genome catalogue for subsequent studies. Furthermore, multiple strategies to link identified phage to their host bacterium will be evaluated. The student will also be involved in the integration of the virome data with bacteriome, fungome, metabolome and proteome data generated by other groups in the consortium.

Profile

The candidate holds a Master of Science degree in Bioinformatics, Computer Science, Computational Biology, Bioengineering, or equivalent qualifications, or is expected to graduate before October 1st 2017.
The candidate should be graduated with at least one degree of distinction (>68%, KU Leuven eligibility criterion to start a PhD), although higher grades will be considered a plus.
The candidate can work both independently as well as in an international team. Fluency in English is required.
The candidate has strong analytical skills, an appropriate problem-solving attitude, can approach complex issues in a systematic way, is a good planner and able to meet deadlines.

More Information

Work location(s)
1 position(s) available at
KU Leuven
Belgium
Leuven

EURAXESS offer ID: 173810

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