ORGANISATION/COMPANYGSK Vaccines Srl
RESEARCH FIELDBiological sciences › Other
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE28/02/2017 23:00 - Europe/Brussels
LOCATIONItaly › Siena
Netherlands › Utrecht
TYPE OF CONTRACTTemporary
HOURS PER WEEK40
OFFER STARTING DATE01/06/2017
EU RESEARCH FRAMEWORK PROGRAMMEH2020 / Marie Skłodowska-Curie Actions
MARIE CURIE GRANT AGREEMENT NUMBER675106
DISSection (Doctoral Industrial School on Human Skin models for Staphylococcal infections) aims at delivering industry-oriented PhD training in the area of Infection and Immunity. The four selected Early-Stage Researchers (ESRs) will experience an intersectoral training programme encompassing a 18 months of internship in Glaxo Smith Kline Vaccines (GSKVACSRL), based in Siena, Italy, and 18 months internship at Department of “Universitair Medisch Centrum Utrecht” (UMCU), NL. A period of secondment is planned for ESR3 and ERS4. The Program is integrated with complementary courses on dermatology, human skin infections, hydrogel scaffolds, mass spectrometry, and induced pluripotent stem cells technology, that will be held by associate partners.
The students will be enrolled in the PhD school Program at Universitair Medisch Centrum Utrecht for a period of 4 years and will receive a PhD degree in the area of Infection and Immunity
The ESRs will have the chance to learn front-edge technologies and will deal with very important and diverse scientific aspects of Microbiology, Immunology, Biochemistry, Dermatology and Vaccinology.
All students will engage in training-by-research, and will participate in a series of scientific, technical and complementary skills training events.
DISSection (Doctoral Industrial School on Human Skin models for Staphylococcal infections) is a European Industrial Doctorate (EID) funded by the Marie Skłodowska-Curie Actions of Horizon 2020, with the aim of training four young scientists in the area of Infection and Immunity. The scope of the Project is to develop a human skin models. The model will be used and optimized to the following main objectives:
- better understanding of human-specific pathogenesis of S. aureus as well as protective mechanisms against the pathogen;
- development of the first immune-competent human skin models for vaccine research;
- provide alternative methods to animal models.
This represents a good opportunity for students that are willing to grow both in basic science as well as in innovative and applicative experimental research.
Specifically, students will be involved in one of two work packages aimed at:
- Exploit skin equivalent models as well as human skin explants to achieve the following major objectives:
- determine the role of toxins and virulence factors in invasive processes of the skin;
- study the role of immuneevasion factors in bypassing responses of immune-competent skin equivalents;
- characterize S. aureus infection in human skin;
- study the role of neutrophils and macrophages as well as their cooperation against S. aureus.
- Exploit skin equivalent models to achieve the following major objectives:
- establish the first human skin equivalent for vaccine research;
- measure expression of virulence factors and vaccine antigens in bacteria interacting with skin cells;
- assess the response of skin cells to infection in terms of cytokine expression;
- dissect protective mechanisms associated with antibodies, complement factors and professional phagocytes against S. aureus skin pathogenesis;
- improve S. aureus vaccine targets by structural modelling;
- broaden application of the skin model for characterizing skin delivery systems.
The four projects have been defined in:
- ESR1: Project: Human-specific S. aureus pathogenic and immune evasion mechanisms
- ESR2: Project: Characterization of the role of different professional phagocytes and their cooperation against S. aureus
- ESR3: Project: Human skin model for vaccine research
- ESR4: Project: Structural modelling of S. aureus vaccine targets.
The training programme comprises:
- Research training activities, performed locally, leading to award of the PhD title
- Scientific/technical training courses and activities performed locally and at the project level to train the ESRs in scientific topics, advanced technology and methodologies necessary for the project implementation.
- Transferable skills training to prepare the ESRs for an academic or industrial career will be provided through local and joint training courses.
- Scientific events, such as 3 annual project meetings.
The ESRs will be contractually employed according to Dutch and Italian legislation and will be covered under the social security scheme of Netherlands and Italy. They will monthly receive a Living Allowance, a Mobility Allowance and a Family Allowance (where applicable) compliant with the applicable EC Marie Skłodowska-Curie Actions – ITN general conditions (see http://ec.europa.eu/research/participants/data/ref/h2020/wp/2014_2015/ma... page 49).
At the time of recruitment, i.e., June 1st 2017 applicants must fulfill the following rules:
- applicants must be in possession of the degree (usually the Master Degree) which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited.
- applicants must be ESRs, i.e. must be in the first four years (full-time equivalent research experience) of their research careers and have not yet been awarded a doctoral degree.
- ESR1 and ESR2: applicants can be of any nationality but, at the time of recruitment, may not have resided or carried out their main activity in Netherlands for more than 12 months in the 3 years immediately prior to the enrolment. Short stays such as holidays are not taken into account.
- ESR3 and ESR4: applicants can be of any nationality but, at the time of selection, may not have resided or carried out their main activity in Italy for more than 12 months in the 3 years immediately prior to the enrolment. Short stays such as holidays are not taken into account.
- Other requirements:
- ESR1: Basic knowledge: Microbiology, Immunology
- ESR2: Basic knowledge: Cell Biology, Immunology
- ESR3: Basic knowledge: Microbiology, Cell Biology
- ESR4: Basic knowledge: Biochemistry
- The CV must be without gaps, in order to easily check the mobility and experience rules. CVs that either do not clearly show the applicant’s past experience, or have unexplained gaps, will be considered ineligible.
The applicants must send the following documents to email@example.com before the deadline (February 28th, 2017):
- an updated CV;
- a motivation letter describing their interest for the position;
- reference letter(s) from at least one former supervisors and/or lecturers;
- at least two referees names and contact details;
- extended abstract of master thesis;
- the scan of the Mater degree which would formally entitle him/her to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited. In case the degree has not been obtained yet, it is necessary to send a declaration of the university stating that the degree will be obtained before April 30th, 2017;
- transcript of records (document indicating their ranking and marks within their last year at their Master Degree as well as the courses/modules they have followed);
- Specification of the position they are applying to, and a preference list of the projects for which the applicant is eligible (see below).
- Educational record;
- scientific quality;
- expected individual impact and benefit of the training to the fellow and to the project;
For each position a shortlist will be prepared and notified to the applicants. The first candidate identified at this stage will be invited for two face to face interviews that will be held at GSK and UMCU.
The face-to-face interviews of the 4 candidates will be completed by end of April.
After the notification, the selected candidates are requested to prepare and submit their application for the PhD school at UMCU.
The recruitment date is set on June 1st 2017.
ESR1 and ESR2 will be employed by UMCU for the first 18 months of their fellowship, and by GSK for the second period of the fellowship (months 19-36). ESR3 and ESR4 will be employed by GSK for the first 18 months of their fellowship, and by UMCU for the second period of the fellowship (months 19-36).
Web site for additional job details
REQUIRED EDUCATION LEVELBiological sciences: Master Degree or equivalentOther: Master Degree or equivalent
REQUIRED LANGUAGESENGLISH: Excellent
Applicants must be in possession of the degree (usually the Master Degree) which would formally entitle them to embark on a doctorate, either in the country in which the degree was obtained or in the country in which the researcher will be recruited.
EURAXESS offer ID: 164702