Postdoctoral Position: Deciphering Shigella cross-talks with human colonic immune cells

This job offer has expired

    Institut Pasteur
    Biological sciencesBiology
    Recognised Researcher (R2)
    15/01/2017 00:00 - Europe/Brussels
    France › 75015 Paris

A 3 years postdoctoral position, funded by the Laboratory of Excellence Integrative Biology of Emerging Infectious Diseases (LabEx IBEID: http://www.pasteur.fr/labex/ibeid), is available in the "Molecular Microbial Pathogenesis" Unit led by Prof. Sansonetti at Institut Pasteur in Paris. Starting date January 2017, position in the team led by Dr Armelle Phalipon.

Diarrheal diseases remain the second leading cause of mortality in children under 5 years of age in developing countries. The Gram-negative enteroinvasive bacterium Shigella, the causal agent of bacillary dysentery also termed shigellosis, remains one of the top 5 pathogens leading to severe diarrhea in this target population. To disrupt gut homeostasis, Shigella possesses a large diversity of weapons which act in concert to create an immunosuppressive environment favorable for bacterial establishment within the colonic mucosa. Modulation of host cell functions by Shigella mainly relies on a type III secretion system (T3SS). While manipulation of host innate responses has been extensively studied, mechanisms possibly developed by Shigella to directly interfere with the large diversity of adaptive immune cells subsets present within the colonic mucosa and critical for the establishment of protective immunity have been poorly explored so far.
By using a new Shigella reporter strain and human colonic specimens, this projects aims at (i) phenotyping the targeted cells, (ii) assessing the bacterial mechanisms resulting in their targeting, and (iii) analyzing the functional impact of such a targeting on the identified cell types. Preliminary results using this experimental setting indicate that bacterial targeting indeed occurs. The findings will bring new insights into the knowledge of host-pathogen cross-talks, and offer a new angle for designing new vaccine strategies.


Additional comments

The selected candidate will preferentially have a PhD in immunology (if not in microbiology). Training in multi-color flow cytometry, microscopy, and high-throughput technologies such as RNAseq will be highly appreciated. Knowledge on gut immunity would be a plus.

To apply: Applicants should send their CV, a motivation letter and 3 references to Dr Armelle Phalipon (armelle.phalipon@pasteur.fr)

Web site for additional job details

Work location(s)
1 position(s) available at
Institut Pasteur
75015 Paris
25-28 rue du docteur Roux

EURAXESS offer ID: 154661
EURAXESS old offer ID: 34121335


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