ORGANISATION/COMPANYUniversity of East Anglia
RESEARCHER PROFILEFirst Stage Researcher (R1)
APPLICATION DEADLINE31/05/2017 00:00 - Europe/Brussels
LOCATIONUnited Kingdom › Norwich
TYPE OF CONTRACTOther
Many natural product anticancer agents are so potent that they cannot be used in the clinic due to unwanted side effects. In recent years, the conjugation of these compounds to antibodies that target the molecules to their site of action has led to clinically effective agents. Through a combination of solution and solid phase methods, we are developing routes to synthesise compounds with ultrapotent anticancer activity that can be incorporated into peptide structures for rapid attachment to antibodies (i). We are also developing novel approaches to conjugation methods and new prodrug analogues of the natural products (ii, iii). In this project, we will design new molecules with the potential to become therapeutic agents both through targeting and through the design of prodrugs. The project will be suitable for anyone with an interest in the application of organic synthesis to the development of therapeutic agents.
The project may be available at an earlier start date of 1 April or 1 July 2017 but should be discussed with the primary supervisor in the first instance.
EURAXESS offer ID: 121600
EURAXESS old offer ID: 34107114
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