23/08/2016
The Human Resources Strategy for Researchers

Synthesis of ultrapotent anticancer agents by solid phase methods (SEARCEY_U17SF)

This job offer has expired


  • ORGANISATION/COMPANY
    University of East Anglia
  • RESEARCH FIELD
    Chemistry
  • RESEARCHER PROFILE
    First Stage Researcher (R1)
  • APPLICATION DEADLINE
    31/05/2017 00:00 - Europe/Brussels
  • LOCATION
    United Kingdom › Norwich
  • TYPE OF CONTRACT
    Other
  • JOB STATUS
    Other


Many natural product anticancer agents are so potent that they cannot be used in the clinic due to unwanted side effects. In recent years, the conjugation of these compounds to antibodies that target the molecules to their site of action has led to clinically effective agents. Through a combination of solution and solid phase methods, we are developing routes to synthesise compounds with ultrapotent anticancer activity that can be incorporated into peptide structures for rapid attachment to antibodies (i). We are also developing novel approaches to conjugation methods and new prodrug analogues of the natural products (ii, iii). In this project, we will design new molecules with the potential to become therapeutic agents both through targeting and through the design of prodrugs. The project will be suitable for anyone with an interest in the application of organic synthesis to the development of therapeutic agents.

The project may be available at an earlier start date of 1 April or 1 July 2017 but should be discussed with the primary supervisor in the first instance.

Web site for additional job details

Work location(s)
1 position(s) available at
University of East Anglia
United Kingdom
Norwich
University of East Anglia, Norwich Research Park, Norwich

EURAXESS offer ID: 121600
EURAXESS old offer ID: 34107114

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