Job Information
- Organisation/Company
- ENS-lyon
- Research Field
- Biological sciences » Biology
- Researcher Profile
- First Stage Researcher (R1)
- Country
- France
- Application Deadline
- Type of Contract
- Temporary
- Job Status
- Full-time
- Offer Starting Date
- Is the job funded through the EU Research Framework Programme?
- HE / MSCA
- Is the Job related to staff position within a Research Infrastructure?
- No
Offer Description
We are pleased to announce a fully-funded PhD position within the Marie Skłodowska-Curie Actions Doctoral Network NERVSPAN (https://nervspan.excitingworms.eu ). NERVSPAN will train 11 Doctoral Students at 7 academic institutions and 2 companies in Austria, Belgium, France, Israel, Netherlands, and the UK.
Project
We recently found that parental perception of pheromone impacts germline development and minimum generation time in the progeny. In contrast to other examples of inter-generational memory in C. elegans which involve very different mechanisms of sensing that do not rely on the parental nervous system or environmental stimuli such as temperature that likely act directly on all cells, including the germ cells, this represent a unique and well controlled system to explore how neuronal signals are transmitted and interpreted in the next generation(s) to generate phenotypic variation.
Therefore, we now want to systematically characterize the molecular changes induced by parental perception of pheromone using transcriptomics. Our preliminary data show that parental exposure to pheromone impacts neuronal specific gene expression in the progeny during early embryo development. The objective is now to characterize cell- and time specific expression changes by collecting time resolved single-cell transcriptomic data during embryo development and analyse the data in combination with resources that are uniquely available in C. elegans such as complete single cell transcriptomic atlas of embryo development and the wiring of C. elegans nervous system.
Objectives
In this project you will :
- Collect single cell transcriptomic data during embryo development in the progeny of pheromone exposed and control parents.
- Perform an integrative analysis of transcriptomic data in combination with existing data.
Ultimately this analysis will suggest further phenotypic differences induced by parental perception of pheromone as well as the molecular and cellular pathways of signal transmission, interpretation and generation of the phenotypic differences.
Requirements
- Research Field
- Biological sciences » Biology
- Education Level
- Master Degree or equivalent
Candidates must comply with the following requirements:
- Have not been resident or have conducted main activity (studies, work, etc.) for more than 12 months within the last three years in France
- Have not been awarded a doctoral degree
- Be fluent in English
The candidate should have carried out a Master's Degree thesis and/or an internship in one of the following disciplines: biology, genetics, genomics, cell biology, computational biology, neuroscience.
Prior experience with C. elegans is appreciated, but not mandatory.
- Languages
- ENGLISH
- Level
- Excellent
Additional Information
Joining a Marie Skłodowska-Curie Actions (MSCA) Doctoral Networks provides a range of benefits to doctoral candidates, including:
- Enrolment in a local PhD school
- Access to state-of-the-art research and supervision by recognized experts
- Participation in network-wide training activities, workshops and conferences
- Secondments periods at other network partners’ labs
International mobility: MSCA networks enable doctoral candidates to undertake their research in different countries, promoting international collaboration and increasing their exposure to diverse research environments and cultures.
Funding: 3-year full-time employment contract in accordance with the Marie Skłodowska-Curie Action regulations. The program provides funding to support the research and training activities of doctoral candidates, including living allowances, mobility allowances, and research expenses.
- Candidates can be of any nationality
- Candidates must hold a Master Degree or equivalent
- Candidates must comply with MSCA mobility rules, i.e., must not have resided or carried out their main activity (work, studies, etc.) in France for more than 12 months in the 36 months immediately before their recruitment date.
Applicants will be selected on their potential for scientific excellence, their adaptability to work in a multicultural environment. The recruitment process will be transparent, open and equal, following the guidelines of the European Charter for Researchers and the Code of Conduct for the Recruitment of Researchers
The selection procedure will consist of the following steps:
- Eligibility check: A Recruitment Committee will check each application is complete and that applicants fulfil the eligibility criteria
- Remote Evaluation: each eligible application will be evaluated and best candidates selected
- Online interviews: The short-listed candidates will be interviewed by a Selection Committee that will include the recruiting PIs plus one additional consortium member
- Candidates, positively evaluated but not initially called for interviews, will be put on a reserve list.
- Notification of the selection outcomes: Short-listed candidates will be informed about the outcome, and the one selected will be put in touch with the HR Department of the hosting institution to initiate the hiring procedure.
To apply, please send the following documents to mirko.francesconi@ens-lyon.fr (Principal Investigator) and denis.dupuy@inserm.fr (Network Coordinator).
- your CV (ideally in the EUROPASS format).
- a motivation letter outlining your relevant experience and explaining why you are interested in the proposed PhD project.
- confirmation of compliance with the eligibility and mobility requirements.
- the contact details of two scientists that have agreed to provide reference letters.
This PhD project is in co-supervision with Patrick Laurent at the Université Libre de Bruxelles, Belgium.
The deadline for applications is July 14th, 2023.
- Website for additional job details
Work Location(s)
- Number of offers available
- 1
- Company/Institute
- ENS-lyon
- Country
- France
- State/Province
- Auvergne-Rhône-Alpes
- City
- Lyon
- Postal Code
- 69007
- Street
- 46 Allée d'Italie
- Geofield
Where to apply
- mirko.francesconi@ens-lyon.fr
Contact
- State/Province
- Auvergne-Rhône-Alpes
- City
- Lyon
- Website
- Street
- 46 Allée d'Italie
- Postal Code
- 69007
- mirko.francesconi@ens-lyon.fr
- Phone
- +33472728508